Season
- Season 16 2008-09-02
- Season 15 2007-09-04
- Season 14 2006-09-05
- Season 13 2005-09-06
- Season 12 2004-08-31
- Season 11 2003-09-03
- Season 10 2002-09-03
- Season 9 2001-09-04
- Season 8 2000-09-05
- Season 7 1999-09-07
- Season 6 1998-09-15
- Season 5 1997-09-09
- Season 4 1996-09-17
- Season 3 1995-09-11
- Season 2 1994-09-12
- Season 1 1993-09-13
- Season 0 1998-09-16
Episode
- Episode 1: Julianne Moore, Aries Spears, Godsmack
- Episode 2: David Duchovny, Greg Behrendt, OK Go
- Episode 3: Kiefer Sutherland, Joely Fisher, Ben Harper
- Episode 4: Alan Alda, Sophia Bush, Citizen Cope
- Episode 5: Zach Braff, Artie Lange, John Mayer
- Episode 6: Ashton Kutcher, Tracy Morgan, John Mayer
- Episode 7: Dwayne "The Rock" Johnson, Al Franken, air guitar expert Björn Türoque
- Episode 8: Matthew Perry, Xzibit, The Rapture
- Episode 9: Gisele Bundchen, Jim Cramer, Madeleine Peyroux
- Episode 10: Johnny Knoxville, Caroline Rhea, Bonnie "Prince" Billy
- Episode 11: Bob Newhart, Elle Macpherson, Jimmy Carr
- Episode 12: Jennifer Love Hewitt, John Krasinski, Ben Kweller
- Episode 13: Jason Lee, Bridget Moynahan, Chingy
- Episode 14: Marcia Cross, David Gregory, Sam Moore
- Episode 15: Christopher Walken, Michael Clarke Duncan, Scissor Sisters
- Episode 16: Billy Bob Thornton, Mr. T, The Wreckers
- Episode 17: John Stamos, Amy Poehler, Nigella Lawson
- Episode 18: Bob Costas, David Cross, Phoenix
- Episode 19: Dennis Miller, Rachael Ray, Evanescence
- Episode 20: Martin Scorsese, Harland Williams, The Decemberists
- Episode 21: Brian Williams, Scott Wolf, Larry Miller
- Episode 22: Jaime Pressly, Jerome Bettis, Jerry Lee Lewis
- Episode 23: Alex Trebek, Yunjin Kim, Barenaked Ladies
- Episode 24: John Lithgow, Lewis Black, Gomez
- Episode 25: Alec Baldwin, John Cena, Demetri Martin
- Episode 26: Sarah Michelle Gellar, Bob Saget, Robert Randolph & The Family Band
- Episode 27: Helen Mirren, Jim Gaffigan, Basement Jaxx
- Episode 28: Jason Schwartzman, Arielle Kebbel, Jenny Lewis
- Episode 29: Regis Philbin, Alessandra Ambrosio, Dierks Bentley
- Episode 30: Tina Fey, Steven Wright, Barbara Stewart
- Episode 31: Kirsten Dunst, Harry Shearer, Corinne Bailey Rae
- Episode 32: Nathan Lane, Jason Sudeikis, Ben Folds
- Episode 33: Diddy, Joe Buck, Frank Black
- Episode 34: Charles Barkley, Kristin Chenoweth, Cat Power
- Episode 35: The Skeleton Show
- Episode 36: Borat, Jack McBrayer, Mastodon
- Episode 37: John Leguizamo, Arden Myrin, Los Abandoned
- Episode 38: Darrell Hammond, Jesse Bradford, Prof. Kevin Warwick
- Episode 39: Russell Crowe, Jorge Garcia, Dean Karnazes
- Episode 40: Will Ferrell, Tom Everett Scott, Death Cab For Cutie
- Episode 41: Howie Mandel, James Lipton, Mat Kearney
- Episode 42: Meredith Vieira, Greg Grunberg, Old Crow Medicine Show
- Episode 43: Barbara Walters, Dax Shepard, Los Lobos
- Episode 44: Robin Williams, Christian Slater, Panic! At The Disco
- Episode 45: Jack Black & Kyle Gass, Joshua Jackson, Tenacious D
- Episode 46: Elijah Wood, Jon Lovitz, Jud Hale
- Episode 47: Martin Short, Flavor Flav, Damien Rice
- Episode 48: Rachel Weisz, Masi Oka, Army of Anyone
- Episode 49: James Spader, Amy Sedaris, Robyn Hitchcock
- Episode 50: Will Arnett, Alyson Hannigan, Billy Talent
- Episode 51: Ethan Hawke, Jim Gaffigan, The Brand New Heavies
- Episode 52: Hugh Jackman, Tiki Barber, Mike Birbiglia
- Episode 53: Matthew Broderick, Lisa Edelstein, Jet
- Episode 54: Jude Law, Kristen Wiig, The Brian Setzer Orchestra
- Episode 55: Martha Stewart, Brian Posehn, My Morning Jacket
- Episode 56: Lucy Liu, Tillie the Canine Artist
- Episode 57: Tom Brokaw, Ed Helms, Sarah McLachlan
- Episode 58: Jennifer Connelly, Jason Segel, Joan Jett and the Blackhearts
- Episode 59: Kevin Nealon, Angela Kinsey, Deftones
- Episode 60: Rob Lowe, Rashida Jones, Drake Bell
- Episode 61: Julianna Margulies, Aries Spears, Mike Lupica
- Episode 62: Chazz Palminteri, Seth Meyers, TV On The Radio
- Episode 63: Cameron Diaz, Dennis Haysbert, Dashboard Confessional
- Episode 64: Ricky Gervais, Steven R. Schirripa, The Matt Savage Trio
- Episode 65: Jeremy Irons, Terry Crews, Aimee Mann
- Episode 66: Howard Stern, Jim Gaffigan
- Episode 67: Sylvester Stallone, Carla Gugino, Matt Mays & El Torpedo
- Episode 68: Patricia Heaton, Jason Ritter, Tony Bennett
- Episode 69: Ben Stiller, Ving Rhames, Joshua Bell
- Episode 70: Andy Samberg, Stuart Scott, Sean Lennon
- Episode 71: Ewan McGregor, Manny Puig, Jordana Spiro
- Episode 72: Carson Daly, Michelle Trachtenberg, Nellie McKay
- Episode 73: LL Cool J, Abigail Breslin, Gov't Mule
- Episode 74: Placido Domingo, Patton Oswalt, moe.
- Episode 75: Jarod Miller, Dulé Hill, Louis C.K.
- Episode 76: Cedric the Entertainer, Orlando Jones, John Pizzarelli
- Episode 77: Matt Lauer, America Ferrera, Little Big Town
- Episode 78: Donald Trump, Meagan Good, Ron Sexsmith
- Episode 79: David Arquette, Lonny Ross, Chuck "The Iceman" Liddell
- Episode 80: Hilary Swank, Artie Lange, The Black Keys
- Episode 81: Kiefer Sutherland, Jill Hennessy, Gym Class Heroes
- Episode 82: Tracy Morgan, Jim Gaffigan, Sparta
- Episode 83: Brian Williams, Dominic Purcell, Dana Gould
- Episode 84: Megan Mullally, Colin Hanks, Annuals
- Episode 85: Liam Neeson, Ali Larter, Brand New
- Episode 86: Brad Garrett, Sarah Silverman, Peter Bjorn And John
- Episode 87: Kristin Davis, Bob Saget, Paolo Nutini
- Episode 88: Sienna Miller, Goran Visnjic, Paul Weller
- Episode 89: Serena Williams, Donal Logue, Kevin Brennan
- Episode 90: Charlize Theron, Bill Hader, Stars of Track and Field
- Episode 91: Kristin Chenoweth, Mindy Kaling, The Slip
- Episode 92: Dr. Phil McGraw, Emily Deschanel, Calexico
- Episode 93: Cuba Gooding Jr., Joy Behar, Jonathan Katz
- Episode 94: Bob Costas, Ashley Tisdale, Josh Groban
- Episode 95: Dylan McDermott, Michael Urie, Lamb of God
- Episode 96: Martin Lawrence, Hayden Panettiere, Hinder
- Episode 97: Eva Longoria, Fred Willard, Lily Allen
- Episode 98: Drew Barrymore, Marc Maron, The Apples in Stereo
- Episode 99: Nicolas Cage, Natalie Morales, John Mulaney
- Episode 100: Christina Ricci, Alan Cumming, Joshua Radin
- Episode 101: Sen. Chuck Schumer, Tracee Ellis Ross, The Holmes Brothers
- Episode 102: Heather Graham, Lewis Black, Explosions in the Sky
- Episode 103: Jim Carrey, Al Roker, Jonny Lives!
- Episode 104: Jimmy Fallon, Keith Olbermann, Steven Kaplan
- Episode 105: Billy Bob Thornton, J. Alexander, G. Love
- Episode 106: Jim Gaffigan, Liev Schrieber, Solomon Burke
- Episode 107: Jake Gyllenhaal, Lance Armstrong, Bayside
- Episode 108: Larry King, Izabel Goulart, 'Biscuit Lady' Carol Fay
- Episode 109: Anderson Cooper, Rob Corddry, Son Volt
- Episode 110: Ted Koppel, Tom Cavanagh, Relient K
- Episode 111: David Hyde Pierce, Kate Mara, Dr. Dog
- Episode 112: Chris Rock, Christopher Meloni, Mary Weiss with The Reigning Sound
- Episode 113: Andy Richter, Len Berman, The Shins
- Episode 114: Julia Louis-Dreyfus, Harland Williams, Neil deGrasse Tyson
- Episode 115: Jeff Goldblum, Ivanka Trump, Pete Yorn
- Episode 116: Tom Arnold, Rainn Wilson, Jesse Malin
- Episode 117: Bernie Mac, Chris Hansen, Daughtry
- Episode 118: Don Cheadle, Neil Patrick Harris, Shane Mauss
- Episode 119: Adam Sandler, Sarah Thyre, Lindsey Buckingham
- Episode 120: Liv Tyler, Gerard Butler, The Fratellis
- Episode 121: Quentin Tarantino, Jesse L. Martin, Brian Kiley
- Episode 122: Rosario Dawson, Jason Sudeikis, Martina McBride
- Episode 123: Ice Cube, B.J. Novak, Clap Your Hands Say Yeah
- Episode 124: Diddy, David Gregory, Kaiser Chiefs
- Episode 125: Michael Imperioli, Jim Cramer, Albert Hammond, Jr.
- Episode 126: Jeff Daniels, Zoë Bell, The Alternate Routes
- Episode 127: Martin Short, Cheryl Hines, Cold War Kids
- Episode 128: Tina Fey, Kevin Pollack, Mystery
- Episode 129: Molly Shannon, Tiki Barber, Of Montreal
- Episode 130: Ray Liotta, Mary Lynn Rajskub, Joseph Arthur
- Episode 131: Martha Stewart, Rob Huebel, Ian Edwards
- Episode 132: Darrell Hammond, Andrew W.K., Blue October
- Episode 133: Tyra Banks, Masi Oka, Brandi Carlile
- Episode 134: Garry Shandling, Adam Brody, Ricky Skaggs & Bruce Hornsby
- Episode 135: Dana Carvey, Jasper Redd, Arctic Monkeys
- Episode 136: George Lucas, Will Arnett, Chris Isaak
- Episode 137: Robin Williams, The Glide Ensemble
- Episode 138: Randy Jackson, Patton Oswalt, Frisbee Golf National Champion David Feldberg, Bob Weir & RatDog
- Episode 139: Snoop Dogg, Tom Waits
- Episode 140: Amanda Peet, Morgan Spurlock, Secondhand Serenade
- Episode 141: Zach Braff, D. J. Qualls, Jimmy Carr
- Episode 142: Howie Mandel, Criss Angel, Patrick Wolf
- Episode 143: Lindsay Lohan, Larry the Cable Guy, Stephen Marley featuring Damien
- Episode 144: Antonio Banderas, Sarah Chalke, The Avett Brothers
- Episode 145: William Shatner, Eric Dane, mtvU's Best Music on Campus Winner
- Episode 146: Tom Selleck, John Stamos, Dan Mintz
- Episode 147: Rebecca Romijn, Donald Faison, Silversun Pickups
- Episode 148: Amy Poehler, Dave Annable, M. Ward
- Episode 149: Luke Wilson, Oscar Nuñez, Blonde Redhead
- Episode 150: Dominic Monaghan, Chris 'Ludacris' Bridges, Rickie Lee Jones
- Episode 151: Amy Sedaris, Lester Holt, Loudon Wainwright III
- Episode 152: America Ferrera, Eddie Izzard, Mark 'Dr. Bugs' Moffett
- Episode 153: Mike Myers, Seth Rogen, The Academy Is...
- Episode 154: Dane Cook, 'Dancing With the Stars' winner Apolo Anton Ohno, Mando Diao
- Episode 155: Paul Rudd, Elisha Cuthbert, Kings of Leon
- Episode 156: Brian Williams, Leslie Mann, Los Straitjackets with Big Sandy
- Episode 157: Debra Messing, Marc Maron, Nelly Furtado
- Episode 158: Marg Helgenberger, Steven R. Schirripa, John Mulaney
- Episode 159: Nicole Richie, Billy Connolly, Crowded House
- Episode 160: Seth Green, Eli Roth, EL-P
- Episode 161: Tim Russert, Ginnifer Goodwin, Feist
- Episode 162: Kevin Dillon, Jim Cramer, Patty Griffin
- Episode 163: Kyra Sedgwick, John Cena, Andrew Bird
- Episode 164: Jessica Alba, Bear Grylls, Paul F. Tompkins
- Episode 165: Tea Leoni, Tyrese Gibson, The White Stripes
- Episode 166: Steve Carell, Jennifer Esposito, Flight of the Conchords
- Episode 167: Wanda Sykes, Nick Offerman, illusionist Hans Klok with Pamela Anderson
- Episode 168: John Krasinski, Louis CK, The Mooney Suzuki
- Episode 169: Lauren Graham, Steve Zahn, Rooney
- Episode 170: Jarod Miller, Jason Priestley, Dan Naturman
- Episode 171: Denis Leary, Mark Consuelos, Against Me!
- Episode 172: Daniel Radcliffe, Carlos Mencia, Art Brut
- Episode 173: Emma Watson, Patton Oswalt, Mark Ronson
- Episode 174: Jason Sudeikis, Janeane Garofalo, They Might Be Giants
- Episode 175: Christopher Walken, Tim Meadows, Nick Lowe
- Episode 176: Jessica Biel, Artie Lange, The Cribs
- Episode 177: Adam Sandler, Vera Farmiga, Pegi Young
- Episode 178: Queen Latifah, Matt Groening, Fountains of Wayne
- Episode 179: Kevin James, Jordana Spiro, Greg Giraldo
- Episode 180: John Leguizamo, James Blake, Marc Broussard
- Episode 181: Andy Samberg, Harry Shearer, Tegan & Sara
- Episode 182: Seth Rogen, Ann Curry, wine expert Gary Vaynerchuk
- Episode 183: Anne Hathaway, Harland Williams, Mavis Staples
- Episode 184: Jackie Chan, Simon Pegg, Just Jack
- Episode 185: Chris Tucker, Tori Spelling, Shiny Toy Guns
- Episode 186: Glenn Close, Michael Cera, Modest Mouse
- Episode 187: Claire Danes, Jonah Hill, Teddy Thompson
- Episode 188: Cuba Gooding, Jr., Jackie Hoffman, Bruce Perry
- Episode 189: Amanda Bynes, Judd Apatow, Straylight Run
- Episode 190: Bob Saget, Maggie Q, Shane Mauss
- Episode 191: Jeff Goldblum, Devon Aoki, Okkervil River
- Episode 192: Kelly Preston, Ryan Reynolds, Ozomatli
- Episode 193: Kevin Bacon, Will Forte, Eisley
- Episode 194: Scarlett Johansson, Kevin Nealon, Locksley
Late Night with Conan O'Brien Season 14 Tea Leoni, Tyrese Gibson, The White Stripes
Stepping into the late-late slot vacated by David Letterman, Conan O'Brien stars in a show that far outdoes its competition in sheer strangeness. Along with the celebrity interviews and musical numbers typical of late-night talk shows, this program make frequent use of odd walk-on characters and frequent "visits" from celebrity guests.
